DNA vaccine containing tumor-associated gene and cytokine...

Details DNA vaccine containing tumor-associated gene and cytokine... DNA vaccine containing tumor-associated gene and cytokine...

2006-11-07

2006-11-07

Guzo, David (Department: 1636)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C536S023100, C536S023400

Reexamination Certificate

active

07132407

ABSTRACT:
The present invention discloses a DNA vaccine and the method of preparation preparing the same, which employs DNA recombination technique to co-incorporate a fragment of tumor-associated gene and a fragment of cytokine gene into a vector. The administration of such DNA vaccine can enhance the immune response of the host through the co-expression of tumor-associated protein and cytokine, and thereby achieve the therapeutic effect of inhibiting or retarding tumor growth.

REFERENCES:
patent: 5998174 (1999-12-01), Glorioso et al.
patent: 6797506 (2004-09-01), Cotten et al.
patent: 2002/0193329 (2002-12-01), Hand-Zimmermann et al.
Pasquini et al., Gene Therapy, Apr. 2002, vol. 9, pp. 503-510.
Lin et al., Mol. Therapy, 2004, vol. 10, No. 2, pp. 290-301.

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