DNA vaccine compositions and methods of use

Details DNA vaccine compositions and methods of use DNA vaccine compositions and methods of use

2004-09-15

2009-02-10

Chen, Shin-Lin (Department: 1632)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

C424S207100, C435S320100, C435S455000, C514S04400A, C536S023720, C536S024100

Reexamination Certificate

active

07488485

ABSTRACT:
The present invention is directed to a DNA vaccine for immunization against HIV. The invention comprises a DNA molecule that has a sequence encoding a plurality of viral proteins capable of stimulating an immune response against HIV. The DNA molecule is rendered safe for use as a vaccine by the disruption of genes encoding reverse transcriptase, integrase, and Vif. The DNA molecule is further rendered safe by at least a partial deletion of the 3′ LTR.

REFERENCES:
patent: 5846546 (1998-12-01), Hurwitz et al.
patent: 6531123 (2003-03-01), Chang
patent: 2003/0158131 (2003-08-01), Aldovini
Potter et al., 2004, Indian J Med Res, vol. 119, pp. 217-237.
Titti et al., 2007, Expert Opin. Emerging Drugs, vol. 12, No. 1, p. 23-48.
McCluskie et al., 1999, Molecular Medicine, vol. 5, p. 287-300.
Smith et al.; Preparation and Induction of Immune Responses by a DNA AIDS Vaccine; Journal; 2000; pp. 343-351; Viral Immunology, vol. 13, No. 3; Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, California. (Under 37 C.F.R. Section 1.97(c)(1) each item of information contained in this Information Disclosure Statement was cited in the corresponding International Searching Authority Invitation to Pay Additional Fees dated May 25, 2005 and enclosed herewith.).
Notification of and Transmittal of the International Search Report and the Written Opinion of the International Searching Authority, or the Declaration, Jul. 21, 2005.
Notification of and Transmittal of International Preliminary Report on Patentability, Mar. 16, 2006.

Affiliated with

Also associated with

Rating

DNA vaccine compositions and methods of use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with DNA vaccine compositions and methods of use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and DNA vaccine compositions and methods of use will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4091720