DNA vaccine compositions and methods of use

Details DNA vaccine compositions and methods of use DNA vaccine compositions and methods of use

2011-08-23

2011-08-23

Chen, Shin-Lin (Department: 1632)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

C424S204100, C536S023720, C536S024100

Reexamination Certificate

active

08003113

ABSTRACT:
The present invention is directed to a DNA vaccine for immunization against HIV. The invention comprises a DNA molecule that has a sequence encoding a plurality of viral proteins capable of stimulating an immune response against HIV. The DNA molecule is rendered safe for used as a vaccine by the disruption of genes encoding reverse transcriptase, integrase, and Vif. The DNA molecule is further rendered safe by at least a partial deletion of the 3′ LTR.

REFERENCES:
patent: 7488485 (2009-02-01), Narayan et al.
Potter et al., 2004, Indian J Med Res, vol. 119, pp. 217-237.
Titti et al., 2007, Expert Opin. Emerging Drugs, vol. 12, No. 1, p. 23-48.
McCluskie et al., 1999, Molecular Medicine, vol. 5, p. 287-300.
Garmory, Helen S., et al., DNA vaccines: improving expression of antigens, Genetic Vaccines and Therapy 2003, 1, http://www.gvt-journal.com/content/1/1/2.
Current Protocols in Molecular Biology, 2006 by John Wiley & Sons, Inc., Chapter 8, pp. 8.0.3-8.5.10.
Osmanov, S. et al. HIV-1 Genetic Variability: Implications for the Development of HIV Vaccines, Development and Applications of Vaccines and Gene Therapy in AIDS, 1996 (http://data.unaids.org/publications/irc-pub05
apoli—en.html).
Sopper et al., Macaque animal model for HIV-induced neurological disease,Journal of Neural Transmission, 2002 p. 747-766.

Affiliated with

Also associated with

Rating

DNA vaccine compositions and methods of use does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with DNA vaccine compositions and methods of use, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and DNA vaccine compositions and methods of use will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2670579