DNA vaccine

Chemistry: molecular biology and microbiology – Vector – per se

Reexamination Certificate

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Details

C514S04400A, C536S023400

Reexamination Certificate

active

08053231

ABSTRACT:
The present invention relates to a DNA vaccine consisting of a vector expressing a part or the whole of a polypeptide regulating production of an inflammatory cytokine, a pharmaceutical composition comprising the DNA vaccine, and a method of preventing or treating an inflammatory disease by using the pharmaceutical composition.

REFERENCES:
patent: 5986060 (1999-11-01), Li et al.
patent: 2002/0090379 (2002-07-01), Mouritsen et al.
patent: WO 95/05849 (1995-03-01), None
Onodera, S. et al., “A novel DNA vaccine targeting macrophage migration inhibitory factor protects joint inflammation and destruction in murine models of arthritis”, Feb. 2007, Arthritis and Rheum., vol. 56: pp. 521-530.
Dalum et al., “Therapeutic antibodies elicited by immunization against TNF-α,” Nature Biotechnology, Jul. 1999, 17:666-669.
Hertz et al., “Active Vaccination Against IL-5 Bypasses Immunological Tolerance and Ameliorates Experimental Asthma,” The Journal of Immunology, 2001, 167:3792-3799.
Wildbaum et al., “Beneficial Autoimmunity to Proinflammatory Mediators Restrains the Consequences of Self-Destructive Immunity,” Immunity, Nov. 2003, 19:679-688.
American Journal of Tropical Medicine and Hygiene, 2000, 62(3,Supp):193-194, Meeting info.: 49thAnnual Meeting of the American Society of Tropical Medicine and Hygiene, Houston, Texas, Oct. 29-Nov. 2, 2000.
Zang et al., “Homologues of Human Macrophage Migration Inhibitory Factor from a Parasitic Nematode,” J. Biol. Chem., Nov. 15, 2002, 277(46):44261-44267.

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