DNA vaccination for induction of suppressive T cell response

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435455, 4353201, 435 691, 800 9, 424 921, A01N 4304, A61K 3170, C12N 1500, C12N 1563

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059394005

ABSTRACT:
A pro-inflammatory T response is specifically prevented by the injection into a recipient of DNA encoding the variable region of a T cell receptor. In response to the vaccination, T cells expressing the variable region produce Th2 cytokines, including IL-4. A pro-inflammatory T cell response directed to an autoantigen is shown to be suppressed by DNA vaccination. The suppressive vaccination further reduced the inflammatory effect of T cells reactive against epitopes of the autoantigen not recognized by the variable region used for vaccination.

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