Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1996-02-26
1999-08-17
Crouch, Deborah
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
435455, 4353201, 435 691, 800 9, 424 921, A01N 4304, A61K 3170, C12N 1500, C12N 1563
Patent
active
059394005
ABSTRACT:
A pro-inflammatory T response is specifically prevented by the injection into a recipient of DNA encoding the variable region of a T cell receptor. In response to the vaccination, T cells expressing the variable region produce Th2 cytokines, including IL-4. A pro-inflammatory T cell response directed to an autoantigen is shown to be suppressed by DNA vaccination. The suppressive vaccination further reduced the inflammatory effect of T cells reactive against epitopes of the autoantigen not recognized by the variable region used for vaccination.
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Steinman Lawrence
Waisman Ari
Crouch Deborah
Martin Jill D.
Sherwood Pamela J.
The Board of Trustees of the Leland Stanford Junior University
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