DNA threading intercalators

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C435S006120, C546S010000

Reexamination Certificate

active

07902362

ABSTRACT:
The invention is directed to a compound having the general formula (1):wherein each of Laand Lbis an independently selected from a linking moiety comprising 0 to 10 main chain atoms, optionally substituted;each of Zaand Zbis an independently selected complexing moiety comprising at least one nitrogen atom;either both or one of Zaand/or Zbis coordinatively bonded to a respective transition metal complex MaVaand MbVbthrough said nitrogen atom, whereineach of Maand Mbis an independently selected transition metal, and each of Vaand Vbis an independently selected valence group.

REFERENCES:
patent: 6368807 (2002-04-01), Makino et al.
patent: 2001/0014452 (2001-08-01), Makino et al.
patent: 2002/0012917 (2002-01-01), Makino et al.
patent: 2005/0214471 (2005-09-01), Theobald et al.
patent: 644413 (1964-06-01), None
patent: 1064627 (1967-04-01), None
patent: 2001165894 (2001-06-01), None
patent: 0240479 (2002-05-01), None
patent: 02057488 (2002-07-01), None
patent: 02066679 (2002-08-01), None
patent: 02053571 (2002-11-01), None
Bilyk, A. et al.: Guest-induced assembly of a chiral metallomacrocycle. J. Chem. Soc. Chem. Commun. vol. 16, pp. 1697-1698, 1995.
Stellet, V. et al.: Self-stacking of naphthalene bis(dicarboximide)s probed by NMR. J. Chem. Soc. Perkin Trans. 2, pp. 1547-1558, 1999.
Ghiggino, K. P. et al.: Modulating electron transfer in a simple bichromophoric system employing axial-ligation as an organising precept. J. of the inclusion phenom. and Macrocyc. Chem. , vol. 49, pp. 27-32, 2004.
Compound with RN 182321-03-5.
Takenaka et al., “DNA sensing on a DNA probe-modified electrode using ferrocenylnaphthalene diimide as the electrochemically active ligand”, Anal Chem 72:1334-41 (2000).
Dixon et al., “Effect of DNA scaffolding on intramolecular electron transfer quenching of a photoexcited ruthenium (II) polypyridine naphthalene diimide”, Inorg. Chem. 38:5526-34 (1999).
Zhang et al. “Enzyme-amplified amperometric detection of 3000 copies of DNA in a 10-μL droplet at 0.5 fM concentration”, Anal Chem 75:3267-3269 (2003).
Dequaire et al., “Screen printing of nucleic acid detecting carbon electrodes”, Anal Chem 74:4370-4377 (2002).
Patolsky et al., “Amplified DNA detection by electrogenerated biochemiluminescence and by the catalyzed precipitation of an insoluble product on electrodes in the presence of doxorubicin intercalator”, Angew. Chem. Int. Ed. 41(18):3398-3402 (2002).
Armistead et al., “Modification of indium tin oxide electrodes with nucleic acids: detection of attomole quantities of immobilized DNA by electrocatalysis”, Anal Chem 72:3764-70 (2000).
Gore et al., “Detection of attomole quantitites of DNA targets on gold microelectrodes by electrocatalytic nucleobase oxidation”, Anal Chem 75:6586-6592 (2003).
Xie e al., “Amperometric detecation of nucleic acid at femtomolar levels with a nucleic acid/electrochemical activator bilayer on gold electrode”, Anal Chem 76:1611-1617 (2004).
Steullet et al., “Studies of Naphthalene diimides as DNA-binding agents”, First International Electronic Conference on Synthetic Organic Chemistry, pp. 1-17, Sep. 1-30, 1997.
Doherty et al., Electrocatalytic Oxidation of Ascorbic Acid at [Osmium(2.2′-bipyridyl)-(poly-4-vinylpyridine)10CI]CI Modified Electrodes; Implications for the Development of Biosensors Based on Osmium-containing Redox Relays, Analysis, vol. 120:2371-2376 (Sep. 1995).
Hossian et al., “Syntheses, Spectroelectrochemistry and Photoinduced Electron-Transfer Processes of Novel Ru and Os Dyad and Triad Complexes with Functionalized Diimide Ligands”, Collections of Czechoslavak Chemical Communications, vol. 66(2), p. 307-337 (2001).
Sato et al. “Ferrocenyl naphthalene diimide can bind to DNA RNA hetero duplex: potential use in an electronchemical detection of MRNA expression”, Journal of Organometallic Chemistry, 637-639, 476-483 (2001).
Schuetz et al. “Basically alkyated imides of naphthalene-1, 4, 5, 8, -tetracarboxylic acid and their chemotherapeutic properties”, Arzneimittel-Forschung vol. 21(6) p. 739-763 (1971).
Steullet V et al. “Design synthesis and DNA-cleavage of Gly-Gly-His-napthalene diimide conjugates” Bioorganic and Medicinal Chemistry letters, vol. 9 (20) p. 2935-2940 (1999).
Takenaka S., “Synthetic threading intercalators as a new analytical probe for necleic acid and gene detection”, Bunseki Kagaku, vol. 48(12), p. 1095-1105 (1999).
Takenaka S. et al. “Selective stabilization of a bulged duplex of d(GCGAAAGCG) oligonucleotide by thymine base-substituted naphthalene diimide”, Chemical Communications (Cambridge) vol. 1 p. 115-116 (1997).
Zhao W. et al. “Preparation and electrochemistry of aromatic polymides on the electrode surface” Quingado Daxue Xubao, Gongcheng Jishuban BianJibu, vol. 11(4). p. 1-10 (1996).
Supplemental European Search Report in related European Application No. 05742652.0 dated Apr. 22, 2010.
Tansil et al., “An ultrasensitive nucleic acid biosensor based on the catalytic oxidation of guanine by a novel redox threading intercalator”,Chem. Commun., 2005, pp. 1064-1066.
Tansil et al., “Direct Detection of DNA with an Electrocatalytic Threading Intercalator”,Anal. Chem., Jan. 1, 2005, vol. 77, No. 1, pp. 126-134.

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