DNA that encodes a tumor necrosis factor inhibitory protein and

Details DNA that encodes a tumor necrosis factor inhibitory protein and DNA that encodes a tumor necrosis factor inhibitory protein and

1992-04-30

1997-12-09

Draper, Garnette D.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 695, 4352523, 43525233, 4353201, 536 235, C12P 2106, C07H 2100

Patent

active

056959532

ABSTRACT:
Tumor Necrosis Factor (TNF) Inhibitory Protein is isolated and substantially purified and the DNA that encodes the TNF inhibitory protein, vectors, host cells, and a recombinant method for producing the encoded protein are also set forth. It has the ability to inhibit: (a) the binding of TNF to its receptors, and (b) the cytotoxic effect of TNF. TNF Inhibitory Protein and salts, functional derivatives and active fractions thereof can be used to antagonize the deleterious effects of TNF.

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