DNA synthetase

Details DNA synthetase DNA synthetase

2007-05-01

2007-05-01

Zeman, Robert A. (Department: 1645)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C530S395000, C530S820000, C530S825000, C435S069100

Reexamination Certificate

active

10343049

ABSTRACT:
The object of the invention is to provide proteins that have both DNA primase activity and DNA polymerase activity. This subject is solved by a protein (p41) that has an amino acid sequence shown in SEQ ID NO: 1. This is for the first time that proteins that have both DNA primase activity and DNA polymerase activity were found. A protein (p46) that has amino acid sequence shown in SEQ ID NO: 2 forms a complex with p41, and enforces DNA synthesis activity that is independent and/or dependent from primer of p41.

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Bocquier et al. (Current Biology, Mar. 20, 2001, vol. 11, pp. 452-456).
Augustin et al. (Nature Structural Biology, Jan. 2001, vol. 8 No. 1, pp. 57-61).
STIC search report on SEQ ID No. 1.
Desogus et al,Nucleic Acids Research, 27:4444-4450 (1999).
Augustin et al,Nature Structural Biology, 8:57-61 (2001).
Bocquier et al,Current Biology, 11(6):452-456 (2001).
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Tseng et al,Biochemistry, 39(7):1646-1654 (2000).
Kawarabayashi et al,DNA Res., 5(2):55-76 (1998).

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