Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1994-06-09
1997-09-23
Allen, Marianne P.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530402, 536 235, 536 231, C07K 14435, C12N 1511
Patent
active
056706219
ABSTRACT:
DNA structure specific recognition protein of eukaryotic origin and DNA encoding such a factor, as well as probes specific for DNA structure specific recognition protein or DNA encoding it and methods of detecting DNA structure specific recognition protein in eukaryotic cells. In particular, a mammalian cellular factor that selectively recognizes and binds DNA damaged or modified by a drug (the anticancer drug, cis-diamminedichloroplatinum (II) or cisplatin) has been identified.
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Brown Steven J.
Bruhn Suzanne L.
Donahue Brian A.
Essigmann John M.
Kellett Patti J.
Allen Marianne P.
Massachusetts Institute of Technology
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