Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing a carotene nucleus
Patent
1999-06-18
2000-11-21
Nashed, Nashaat T.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing compound containing a carotene nucleus
435148, 435189, 4352523, 43525233, 4353201, 536 232, 536 237, C12P 2300, C12P 726
Patent
active
061501301
ABSTRACT:
Disclosed are the following DNA strands relating to the synthesis of keto group-containing xanthophylls such as astaxanthin and the like, and the techniques relating to the production of xanthophylls by genetic engineering:
A DNA strand having a nucleotide sequence which encodes a polypeptide having an enzyme activity for converting a methylene group at the 4-position of a .beta.-ionone ring into a keto group.
A DNA strand having a nucleotide sequence which encodes a polypeptide having an enzyme activity for converting a methylene group at the 4-position of a 3-hydroxy-.beta.-ionone ring into a keto group.
A DNA strand having a nucleotide sequence which encodes a polypeptide having an enzyme activity for adding a hydroxyl group to the 3-carbon of a 4-keto-.beta.-ionone ring.
It is possible to produce a variety of xanthophylls such as canthaxanthin, astaxanthin and the like by introducing the DNA strands into an appropriate microorganism such as Escherichia coli and the like.
REFERENCES:
Yokoyama, A., et al., "Production of Astaxanthin and 4-Ketozeaxanthin by the Marine Bacterium, Agrobacterium aurantiacum," Bioschi. Biotech. Biochem., vol. 58, No. 10, pp. 1842-1844 (Oct. 1, 1994).
Misawa, N., et al., "Elucidation of the Erwinia uredovora Carotenoid Biosynthetic Pathway by Functional Analysis of Gene Products Expressed in Escherichia coli," Journal of Bacteriology, vol. 172, No. 12, pp. 6704-6712 (Dec. 1990).
Johnson, E., et al., "Astaxanthin from Microbal Sources," Critical Reviews in Biotechnology, vol. 11, No. 4, pp. 297-326 (1991).
N. Misawa et al., "Elucidation of an Astaxanthin Biosynthetic Pathway at the Level of the Biosynthesis Genes", Chemical Abstracts, vol. 123, No. 11, Sep. 1995.
Kajiwara Susumu
Kondo Keiji
Misawa Norihiko
Yokoyama Akihiro
Kirin Beer Kabushiki Kaisha
Marine Biotechnology Institute Co., Ltd.
Nashed Nashaat T.
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