Chemistry: electrical and wave energy – Apparatus – Electrophoretic or electro-osmotic apparatus
Patent
1994-08-10
1996-07-09
Niebling, John
Chemistry: electrical and wave energy
Apparatus
Electrophoretic or electro-osmotic apparatus
204612, 204616, 204608, G01K 2726, G01N 27447
Patent
active
055341250
ABSTRACT:
To sequence DNA, DNA samples marked with flourscent infrared dye are applied at a plurality of locations for electrophoresing in a plurality of channels through a gel electrophoresis slab. The channels are scanned with a laser and a sensor, that include a microscope focused on the gel slab. The focal point and slab are adjusted with respect to each other so that the focal point of the microscope remains on the gel slab during a scan. The data from the scan is directly used to amplitude modulate density readings on a display, and the scan is displayed in a horizontal sweep of a cathode ray tube, whereby said cathode ray tube provides intensity displays of bands representing DNA. Different sizes of glass gel sandwiches may be mounted to the same console for different sequencing tasks.
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Bruce Robert C.
Eckles Robert D.
Middendorf Lyle R.
Carney Vincent L.
Li-Cor Inc.
Niebling John
Starsiak Jr. John S.
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