DNA sequences with increased expression of HBcAg

Details DNA sequences with increased expression of HBcAg DNA sequences with increased expression of HBcAg

1991-08-01

1992-12-29

Schwartz, Richard A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C12N 1551

Patent

active

051752727

ABSTRACT:
The invention relates to increased expression of HBcAg. DNA Sequences are disclosed which exhibit increased levels of expression of HBcAg. Increased levels of expression is also achieved by various modifications of the HBcAg sequences.

REFERENCES:
patent: 4710463 (1987-12-01), Murray
Yie et al, "High level expression of HBcAg in E. coli by modification of the 5'end of the HBc gene," Chinese Journal of Virology 4(4):312-318 (1988).
Kim et al, "Expression and Secretion of Hepatitis B Viral Mutant Core Antigen" Korean Journal of Microbiology 27(3):169-175 (1989).
Grosjean et al. "Preferential codon usage in prokaryotic genes the optimal codon-anticodon interaction energy and the selective codon usage in efficiently expressed genes." Gene 18:199-209 (1982).
R. A. Bhat et al., Hepatology 11:271 (1989).
R. E. Lanford et al., Viral Immunology 1:97 (1987).

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