DNA sequences, recombinant DNA molecules and processes for produ

Details DNA sequences, recombinant DNA molecules and processes for produ DNA sequences, recombinant DNA molecules and processes for produ

1987-03-27

1991-04-02

Martinell, James

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4352523, 43525233, 4353201, 935 11, 935 44, 935 46, 935 73, C12P 2100, C12N 120, C12N 1500

Patent

active

050046896

ABSTRACT:
DNA sequences, recombinant DNA molecules and hosts transformed with them which produce polypeptides displaying a biological or immunological activity of gamma interferon. The genes coding for these polypeptides and methods of making and using these DNA sequences, molecules, hosts, genes and polypeptides are disclosed. The DNA sequences of this invention are further characterized by expression control sequences which permit the production of gamma interferon in high yields. More particularly, these expression control sequences comprise the .lambda. P.sub.L promoter, and more preferably, a trp-derived expression control sequence containing the sequence ATCGATACT between the Shine-Dalgarno sequence and the translational start signal. In appropriate hosts, these DNA sequences and recombinant DNA molecules permit the production and identification of genes and polypeptides displaying a biological or immunological activity of gamma interferon and their use in antiviral, antitumor or anticancer, and immunomodulation agents and methods.

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