DNA sequences of enterically transmitted non-A/non-B hepatitis v

Details DNA sequences of enterically transmitted non-A/non-B hepatitis v DNA sequences of enterically transmitted non-A/non-B hepatitis v

1995-06-07

1998-10-20

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530350, 530324, 536 2372, 435 691, A61K 3800, C07K 100, C07H 2104, C12P 2106

Patent

active

058246495

ABSTRACT:
Viral proteins derived from an enterically transmitted non-A
on-B viral hepatitis agent (HEV) are disclosed. In one embodiment, the protein is immunologically reactive with antibodies present in individuals infected with the viral hepatitis agent. This protein is useful in a diagnostic method for detecting infection by the enterically transmitted agent. Specific epitopes have been identified that are reactive with sera of individual infected with different strains of HEV. Also disclosed are DNA probes derived from a cloned sequence of the viral agent. These probes are useful for identifying and sequencing the entire viral agent and for assaying the presence of the viral agent in an infected sample, by using probe-specific amplification of virus-derived DNA fragments.

REFERENCES:
patent: 4659678 (1987-04-01), Forrest et al.
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4870026 (1989-09-01), Wands et al.
patent: 4871659 (1989-10-01), Pillot
patent: 5077193 (1991-12-01), Mishire et al.
Sarthou, J.I., et al., "Characterization of an Antigen-Antibody System Associated with Epidemic Non-A, Non-B Hepatitis in West Africa and Experimental Transmission of an Infectious Agent to Primates," Ann. Inst. Pasteur/Virol. 137(F): 225-232 (1986).

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