DNA sequences involved in neuronal degeneration, multicellular o

Details DNA sequences involved in neuronal degeneration, multicellular o DNA sequences involved in neuronal degeneration, multicellular o

1990-05-30

1993-03-23

Wax, Robert A.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435 29, 435 691, 435 703, 536 235, 935 1, 935 19, 935 38, C12N 500, C07H 1512, C12P 2106, C12Q 168

Patent

active

051963337

ABSTRACT:
This invention provides an isolated nucleic acid molecule encoding a wild-type animal protein associated with neuronal degeneration and an isolated nucleic acid molecule encoding a mutated animal protein associated with neuronal degeneration. Also provided are strains of the nematode Caenorhabditis elegans containing the nucleic acid molecules encoding a mutated C. elegans protein associated with neuronal degeneration. The invention also provides methods for detecting such nucleic acid molecules, for diagnosing degenerative disease, for causing a diseased human cell to degenerate, and for screening drugs to identify drugs which prevent or decrease neuronal degeneration.

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