DNA sequences expressing mammalian alpha-1-antitrypsin

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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4352401, 4352523, 4353201, C12N 1509, C12N 1512, C12N 1515

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053996844

ABSTRACT:
DNA sequences to mammalian .alpha..sub.1 -antitrypsin are provided which can be used for expression of mammalian .alpha..sub.1 -antitrypsin.

REFERENCES:
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Kurachi et al, "Cloning and sequence of cDNA coding for alpha-1-antitrypsin", Proc. Natl. Acad. Sci. USA 78: 6826 (1981).
Woo et al, "the human alpha-1-antitrypsin gene: its sequence homology and structural comparison with the chicken ovalbumin gene", Chem. Abstr. 98: 120615z (1983) of UCLA Symp. Mol. Cell. Biol. 26(Gene Regul.), 55-64 (1982).
Clissold et al, "Molecular cloning of cDNA sequences transcribed from mouse liver endoplasmic reticulum poly(a)mRNA", Gene 15: 225 (1981).
Houghton et al, "the amino-terminal sequence of human fibroblast interferon as deduced from reverse transcripts obtained using synthetic olignucleotide primers", Nucleic Acids Res. 8: 1913 (1980).
Wilson et al:"Isolation of human alpha-1 anti trypsin mRNA from liver tissue for molecular cloning" in J. Supramol. Struct. Cell. Biochem. (Suppl. 5), (1981), 421 presented at the ICN-University of California at Los Angeles, Mar. 15-20, 1981.
Clissold et al: Biol. Abstr. 73, 60806 (1982) abstract of Gene 15, 225 (1981).
Morii et al, "Human alpha-1-antitrypsin, Characterization and N- and C- terminal sequences", J. Biochem. 83: 269 (1978).
Roberts et al, "A general method for maximizing the expression of a cloned gene", Proc. Natl. Acad. Sci. USA 76: 760 (1979).
Goeddel et al; Nucleic Acids Res. 8: 4057 (1980).

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