DNA sequences encoding t-PA derivatives with cleavable sites

Details DNA sequences encoding t-PA derivatives with cleavable sites DNA sequences encoding t-PA derivatives with cleavable sites

1990-11-06

1994-07-05

Hill, Jr., Robert J.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435212, 435226, 4353201, 536 234, 536 235, C12N 500, C12N 1500, C12N 948

Patent

active

053267001

ABSTRACT:
The invention concerns compounds and methods for the recombinant production of a homogeneous population of tissue plasminogen activator molecules and derivatives thereof through the use of heterologous propeptide regions that are uniformly cleaved upon secretion from the host cell.

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