DNA sequences encoding snake venom inhibitors of platelet activa

Details DNA sequences encoding snake venom inhibitors of platelet activa DNA sequences encoding snake venom inhibitors of platelet activa

1989-11-01

1993-01-26

Draper, Garnette D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530324, 530856, 530350, 435 691, 435 696, 4353201, 4352401, 536 235, A61K 3700, C07K 1300, C12N 1512

Patent

active

051822601

ABSTRACT:
The present invention relates to polypeptide inhibitors of platelet activation and derivatives thereof, purified from the venom of the North American Water Moccasin and to methods for their purification. This invention also relates to DNA sequences and recombinant DNA molecules which code for these polypeptide inhibitors of platelet activation. And this invention relates to recombinant DNA molecules which code for fusion proteins comprising both a polypeptide inhibitor of platelet activation and an anti-thrombin polypeptide. This invention also relates to pharmaceutically acceptable compositions and methods characterized by at least one of these natural or recombinant inhibitors of platelet activation, alone or in combination with anti-thrombin compounds. The compositions, combinations and methods of this invention are particularly useful in the treatment of thrombotic diseases.

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