DNA sequences encoding proteins used to elicit and detect progra

Details DNA sequences encoding proteins used to elicit and detect progra DNA sequences encoding proteins used to elicit and detect progra

1992-07-20

1994-11-01

Patterson, Jr., Charles L.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

4352401, C07K 1300

Patent

active

053608933

ABSTRACT:
Polypeptides and mutants and variants associated with programmed cell death in mammalian cells and DNA sequences, and fragments and derivatives thereof, encoding the polypeptides are disclosed. Also disclosed are methods for detecting programmed cell death in mammalian cells, a method of activating programmed cell death in unwanted mammalian cells, and methods for preventing unwanted cell death occurring in degenerative disorders of mammals.

REFERENCES:
Evan, G. I., et al., (1992), Cell 69, 119-128.
Itoh, N., et al., (1991), Cell, 66, 233-243.
Lanotte, M., et al., (1991), J. Cell. Physiol., 146, 73-80.
Cohen, J. J., et al., (1984), J. Immun., 132(1), 38-42.

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