DNA sequences encoding proteins used to elicit and detect progra

Details DNA sequences encoding proteins used to elicit and detect progra DNA sequences encoding proteins used to elicit and detect progra

1994-10-19

1996-06-18

Patterson, Jr., Charles L.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

4352402, 4352523, 536 235, C12N 1512, C12N 1579, C12N 1585, C12Q 168

Patent

active

055276822

ABSTRACT:
Polypeptides and mutants and variants associated with programmed cell death in mammalian cells and DNA sequences, and fragments and derivatives thereof, encoding the polypeptides are disclosed. Also disclosed are methods for detecting programmed cell death in mammalian cells, a method of activating programmed cell death in unwanted mammalian cells, and methods for preventing unwanted cell death occurring in degenerative disorders of mammals.

REFERENCES:
Evan, G. I., et al., (1992) Cell 69, 119-128.
Itoh, N., et al., (1991) Cell 66, 233-243.
Lanotte, M., et al., (1991) J. Cell, Physiol 146, 73-80.
Lee, D. C., et al., (1983) Proc. Natl. Acad. Sci. USA 80, 3608-3612.
Uhler, M.D., er al., (1986) Proc. Natl. Acad. Sci. USA 83, 1300-1304.

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