DNA sequences encoding phospholipase A.sub.2 enzyme and processe

Details DNA sequences encoding phospholipase A.sub.2 enzyme and processe DNA sequences encoding phospholipase A.sub.2 enzyme and processe

1993-01-13

1994-06-21

Hill, Jr., Robert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4352402, 4353201, 435185, 536 231, 536 232, 536 234, 536 235, C12P 2106, C12N 900, C07H 1700

Patent

active

053227760

ABSTRACT:
The invention provides novel DNA and peptide sequences encoding a family of phospholipase A.sub.2 enzymes, with specific activities of approximately 20 .mu.mol/min/mg in the mixed micelle assay. These enzymes are useful in methods for detecting the anti-inflammatory potential of various chemical agents. The invention also details novel methods for determining such potential using the novel sequences, methods for making the novel peptides, and methods for developing new anti-inflammatory drugs.

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S. Moncada et al, "Chapter 28, Prostaglandins, Prostacyclin, Thromboxane A.sub.2, and Leukotrienes" pp. 660-673.

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