DNA sequences encoding novel thrombolytic proteins

Details DNA sequences encoding novel thrombolytic proteins DNA sequences encoding novel thrombolytic proteins

1993-08-06

1995-05-23

Draper, Garnette D.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

536 232, C12N 1558

Patent

active

054181585

ABSTRACT:
Thrombolytic proteins are disclosed which have tissue plasminogen-type activity. The proteins are characterized by modification within the 94 amino acid N-terminus, and/or at Arg-275, and/or at one or more of the N-linked glycosylation sites. Methods for making these proteins are disclosed as are therapeutic compositions containing same.

REFERENCES:
patent: 4766075 (1988-08-01), Goeddel
patent: 5071972 (1991-12-01), Larsen
van Zonneveld, A. J. et al., PNAS, 83: 4670-4674, 1986.

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