DNA sequences encoding human t-PA substituted at position 275 or

Details DNA sequences encoding human t-PA substituted at position 275 or DNA sequences encoding human t-PA substituted at position 275 or

1991-08-05

1992-09-15

Lacey, David L.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

4352402, 4352523, 4353201, 536 27, 424 9463, A61K 32547, C12P 2102, C12N 1558, C12N 948

Patent

active

051476436

ABSTRACT:
Biologically active mutant tissue plasminogen activators are disclosed wherein site directed mutagenesis, for example, of a two-chain activation site renders the mutants resistant to conversion to the two-chain form.

REFERENCES:
patent: 4753879 (1988-06-01), Rosa et al.
Pennica, D., et al., Nature, vol. 301, pp. 214-221, 1983.
Tate, K., et al., Biochemistry, vol. 26, pp. 338-343, 1987.

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