DNA sequences encoding human Myt1 kinase

Details DNA sequences encoding human Myt1 kinase DNA sequences encoding human Myt1 kinase

1996-03-05

1998-04-28

Patterson, Jr., Charles L.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

43525411, 435194, 536 232, C12N 1554

Patent

active

057443491

ABSTRACT:
The invention provides isolated, purified and structurally defined DNA encoding Myt1Hu, isolated and purified Myt1Hu protein, a method for making Myt1Hu protein by expressing the DNA encoding Myt1Hu and methods for measuring levels of Myt1Hu in RNA or of Myt1Hu in a cell sample.

REFERENCES:
Gautier et al., Cdc25 is a Specific Tyrosine Phosphatase That Directly Activates p34.sup.cdc2. Cell. 67:197-211 (1991).
Guan et al., "Isolation and Characterization of a Novel Dual Specific Phosphatase, HVH2, Which Selectively Dephosphorylates the Mitogen-Activated Protein Kinase." J. Biol. Chem. 270(13):7197-7203 (1995).
Honda et al., "Dephosphorylation of Human p34.sup.cdc2 Kinase on Both Thr-14 and Tyr-14 by Human Cdc25B Posphatase." FEBS Letters. 318(3):331-334 (1993).
Kornbluth et al., "Membrane Localization of the Kinase Which Phosphorylates p34.sup.cdc2 on Theonine 14" Mol. Biol. Of the Cell. 5:273-282 (1994).
Kuang et al., "Cdc25 is One of the MPM-2 Antigens Involved in the Activation of Maturation-Promoting Factor." Mol. Biol. Of the Cell. 5:135-145 (1994).
Lee et al., Cdc25.sup.+ Encodes a Protein Phosphatase That Dephosphorylates p34.sup.cdc2. Mol. Biol. of the Cell. 3:73-84 (1992).
Millar et al., "Cdc25 M-Phase Inducer." Cold Spring Harbor Symposia on Quantitative Biology. 56:577-584 (1991).
Mueller et al., "Cell Cycle Regulation of a Xenopus Wee1-like Kinase." Mol. Biol. of the Cell. 6:119-134 (1995).
Parker et al., "Identification of a 95-kDa WEE1-like Tyrosine Kinase in HeLa Cells." Proc. Nat'l Acad. Sci. USA. 92:9638-9642 (1995).
Sebastian et al., "Cdc25M2 Activation of Cyclin-dependent Kinases by Dephosphorylation of Theonine-14 and Tyrosine-15." Proc. Nat'l. Acad. Sci. USA. 90:3521-3524 (1993).
Science, 25 Sep. 1992, vol. 257, pp. 1955-1957; "Inactivation of the p34.sup.cdc2 -Cyclin B Complex by the Human WEE 1 Tyrosine Kinase"; Laura L. Parker and Helen Piwnica-Worms.
Molecular Biology of the Cell, Sep. 1994, vol. 5, pp. 989-1001; "Cell Cycle Regulation of the p34.sup.cdc2 Inhibitory Kinases"; Sue Atherton-Fessler et al.
Science, 6 Oct., 1995, vol. 270, pp. 86-90; Myt1: A Membrane-Associated Inhibitory Kinase That Phosphorylates Cdc2 on Both Threonine-14 and Tyrosine-15; Paul R. Mueller et al.

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