Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1992-09-21
1996-05-07
Jones, W. Gary
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
435 6, 435 691, 4351723, 435810, 536 241, 536 243, 536 2431, 536 2432, 536 2433, 935 77, 935 78, 935 19, C07H 2104
Patent
active
055147879
ABSTRACT:
Human membrane cofactor protein, a protein involved in regulation of complement activity, has been purified to homogeneity. The gene encoding this protein has been retrieved and permits deduction of the entire amino acid sequence and the recombinant production of this material. Pharmaceutical compositions in which MCP is the active ingredient for use in treating autoimmune diseases are also disclosed.
REFERENCES:
Reid, K. B. M. et al, Immunology Today (1986) 7:7 & 8, 230-243, "Complement System Proteins Which Interact with C3b or C4b".
Holers, et al., Immunol. Today (1985) 6:188-192.
Ross, et al., Adv. Immunol. (1985) 37:217-267.
Atkinson, et al., Immunol. Today (1987) 8:212-215.
Purcell et al., Immunology (1990) 70:155-161.
Kim, J. Biol. Chem. (1989) 264(17):9780-9784.
Wong et al., J. Immunol. (1985) 134(6):4048-4056.
Goujet-Zalc et al., Cell. Immunol. (1987) 109:282-294.
Cui et al., Faseb J. (1989) 3:A500, No. 1594.
Seya et al., Biochem. J. (1989) 264: (7 pages of text total).
Yu, et al., J. Clin. Invest. (1986) 78:494-501.
Medof, et al., Proc. Natl. Acad. Sci. (1987) 84:2007-2011.
Caras, et al., Science (1987) 238:1280-1283.
Cole, et al., Proc. Natl. Acad. Sci. (1985) 82:859-863.
Seya, et al., J. Exp. Med. (1986) 163:837-855.
Ballard, et al., J. Immunol. (1987) 138:3850-3855.
Seya, et al., Eur. J. Immunol. (1988) 18:1289-1294.
Seya, et al., Complement (1987) 4:225.
Hourcade, et al., Adv. Immunol. (1989) 45:381-416.
Lublin, et al., Ann. Rev. Immunol. (1989) 7:35-58.
Lublin, et al., J. Exp. Med. (1987) 165:1731-1736.
Lublin, et al., J. Exp. Med. (1988) 168:181-194.
Ballard, et al., J. Immunol. (1988) 141(11):3923-3929.
McNearney, et al., J. Clin. Invest. (1989) 84:001-008.
Seya, et al., submitted for publication in Biochem. J. in Jul. 1989.
Jones W. Gary
Marschael Ardin H.
Washington University
LandOfFree
DNA sequences encoding human membrane cofactor protein (MCP) does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with DNA sequences encoding human membrane cofactor protein (MCP), we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and DNA sequences encoding human membrane cofactor protein (MCP) will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1228172