DNA sequences encoding fusions of DNA repair proteins and uses t

Details DNA sequences encoding fusions of DNA repair proteins and uses t DNA sequences encoding fusions of DNA repair proteins and uses t

1997-10-24

2000-04-04

Elliott, George C.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 691, 4353201, 435325, 435367, 536 231, 536 234, 536 235, C12N 1500, C12N 1563, C12N 1585, C07H 2104

Patent

active

060460369

ABSTRACT:
Described are DNA-repair fusion proteins of multiple, complementary DNA repair proteins and having the activity of each protein, and related polynucleotides and vectors. The proteins, when expressed in cells, e.g., hematopoietic cells, increase the survival rate of the cells when contacted with chemotherapeutic agents. Also described are transgenic animal models wherein these proteins are expressed in essentially all cells of the animal. Such animal models are useful for instance in testing chemotherapeutic agents.

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