Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1987-01-09
1989-07-04
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530324, A61K 3764, C07K 710
Patent
active
048450766
ABSTRACT:
There are described DNA sequences from the genome of mammals, in particular from the human genome, coding for proteins having the biological activity of HUSI-type I inhibitors. There are further described biotechnological methods of the preparation of proteins having the biological activity of HUSI-type I inhibitors as well as pharmaceutical compositions containing said proteins.
REFERENCES:
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Heinzel et al., Chem. Abstr. vol. 105, No. 204140s (1986) (Abstr. of Eur. J. Biochem 160(1) 61-7, 1986).
Egbring et al., Blood, vol. 49, No. 2 (2/1977).
Rote Liste, Editio Cantor Aulendorf/Wurtt (1987).
The Merck Index, 10th edition, Martha Windholz, editor, Merck & Co., Inc., p. 785 (1983).
E. C. Klasen, et al., the N-Terminal Sequence of Antileukoprotease Isolated from Bronchial Secretion, Biochemical & Biophysical Research Communications, vol. 128, No. 1, pp. 285-289, Apr. 16, 1985.
O. Wallner, et al., Characterization of an Acid-Stable Proteinase Inhibitor in Human Cervical Mucus, Hoppe-Seyler's Z. Physiol. Chem. Bd. 355, S 709-715, 1974.
H. Schiessler, et al., Acid-Stable Inhibitors of Granulocyte Neutral Proteases in Human Mucous Secretions: Biochemistry & Possible Biological Function, Neutral Proteases of Human Polymorphonuclear Leukocytes, pp. 195-207, 1978.
H. Fritz, Proteinase Inhibitors in Severe Inflammatory Processes (Septic Shock & Experimental Endotozaemia): Biochemical, Pathophysiological & Therapeutic Aspects Protein Degradation in Health & Disease, Excerpta Medica, 1980, Ciba Foundation.
Appelhans Heribert
Gassen Hans G.
Heinzel Regina
Machleidt Werner
Seemuller Ursula
Chan Christina
Grunenthal GmbH
Phillips Delbert R.
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