DNA sequence useful for the detection of Alzheimer's disease

Details DNA sequence useful for the detection of Alzheimer's disease DNA sequence useful for the detection of Alzheimer's disease

1989-11-30

1993-06-15

Yarbrough, Amelia Burgess

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, 436811, 530324, 935 11, 536 2431, C08B 104

Patent

active

052200132

ABSTRACT:
DNA sequences encoding the beta-amyloid core protein, and beta-amyloid-related proteins associated with Alzheimer's disease are disclosed. These sequences are used in producing or constructing recombinant beta-amyloid core protein, beta-amyloid-related proteins and recombinant or synthetic immunogenic peptides. These sequences are also used to identify genomic mutations and/or restriction site alterations which are associated with a predisposition to Alzheimer's disease, for purposes of genetic screening. Antibodies generated against the recombinant proteins or immunogenic peptides derived therefrom can be used for cerebral fluid or serum protein diagnosis of Alzheimer's disease.

REFERENCES:
patent: 4595674 (1986-06-01), Tschesche et al.
patent: 4666829 (1987-05-01), Glenner et al.
patent: 4912206 (1990-03-01), Goldgaber et al.
Van Nostrand et al., Journal of Biological Chemistry, (1987) 262(18):8508-8514.
Robakis et al., Proc Natl Acad Sci USA 84:4190-4194 (Jun. 1987).
Kang et al., Nature 325:733-736 (Feb. 19, 1987).
Goldgaber et al., Science 235:877-880 (Feb. 1987).
Neve et al., Biological Abstracts 83(6):1987.
Tanzi et al., Science 235:880-884 (Feb. 1987).
Masters et al., Chemical Abstracts 104(15) (Apr. 1986), pp. 506-507.
Masters et al., EMBO J 4(1):2757-2763 (1985).
Uzan et al., Biochem Biophys Res Comm 119:273-281 (Feb. 1984).
Masters et al., Proc Natl Acad Sci USA 82:4245-4249 (Jun. 1985).
Glenner and Wong, Biochem Biophys Res Comm 120(3):885-890 (May 1984).
Glenner et al., Biochem Biophys Res Comm 122:1131-1135 (Aug. 1984).
Glenner et al., "Amyloidosis", published by Plenum Press, Jun. 1986, pp. 693-701.
Roher et al., Proc Natl Acad Sci USA 82:2662-2666 (Apr. 1986).
Wong et al., Proc Natl Acad Sci USA 82:8729-8732 (Dec. 1985).
Ohtsuka et al., Biol Chem 269:2605-2608 (Mar. 1985).
Takahashi et al., Proc Natl Acad Sci USA 82:1931-1935 (Apr. 1985).
Robakis et al., Proc Natl Acad Sci USA 83:6377-6381 (1986).
Allsop et al., Neuroscience Letters 68:252-256 (1986).
Price et al., Drug Development Res 5:59-68 (1985).
Delabar et al., Science 235:1390-1392 (1987).
Barnes, Science 235:846-847 (1987).
Anderton, Nature 325:658-659 (1987).
Selkoe et al., Science 235:873-876 (1987).
Allsop et al., Brain Res 259:348-352 (1983).
Westermark and Cornwell, Amyloidosis, pp. 659-668 (1984).
Allsop et al., Amyloidosis, pp. 723-732 (1984).
St. George-Hyslop et al., Science 235:885-890 (1987).
Ponte et al., Nature, 331(6156):525-527 (1988).
Tanzi et al., Nature 331:528-530 (1988).
Kitaguchi et al., Nature 331:530-532 (1988).
Shivers et al., EMBO J 7(5):1365-1370 (1988).
Dyrks et al., EMBO J 7(4):949-957 (1988).
Marks et al., J Biol Chem 261(16):7115-7118 (1986).
Tan and Kaiser, Biochem 16(8):1531-1541 (1977).
Gebhard et al., Protease Inhibitors, Barrett and Salvesen (eds.), 1986, Elsevier Science Publishers BV, pp. 375-388.
Fritz and Wunderer, Drug Res 33(1):479-494 (1983).
Carrell, Nature (1988) 331:478-479.

Affiliated with

Also associated with

Rating

DNA sequence useful for the detection of Alzheimer's disease does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with DNA sequence useful for the detection of Alzheimer's disease, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and DNA sequence useful for the detection of Alzheimer's disease will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1044143