DNA sequence for uricase and manufacturing process of uricase

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Oxidoreductase

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435 71, 4353201, 4352523, 536 232, C12N 906, C12N 1553

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active

059553367

ABSTRACT:
This invention relates to DNA containing a gene encoding uricase, a plasmid having said DNA, a transformant containing said plasmid, and a process for producing uricase by using said transformant.

REFERENCES:
patent: 3475276 (1969-10-01), Kano
patent: 4882280 (1989-11-01), Takashio et al.
patent: 4987076 (1991-01-01), Takashio et al.
Young, et al., "Efficient isolation of genes by using antibody probes", PNAS, vol. 80, Mar. 1983, pp. 1194-1198.
Nippon Nogeikagaku Kaishi, vol. 63, No. 3, p. 163 (1989), The Agricultural Society Of Japan, Mar. 15, 1989 and English Language translation thereof.
Cloning a cDNA for Drosphila melanogaster urate oxidase (Gene, vol. 45, 131-173 (1986).
Generation of cDNA Probes Directed by Amino Acid Sequence: Cloning of Urate Oxidase (Science, vol. 239, 1288-1291), date N.A.
Primary structure of the soybean nodulin-35 gene encoding uricase II localized in the peroxisomes of uninfected cells of nodules Proc. Natl. Acad. Sci. vol. 82, 5040-5044, Aug., 1985.
Nucleotide sequence of cDNA and predicted amino acid sequence of rat liver uricase (Eur. J. Biochem. vol. 173 459-463 (1988)).
Suggs et al "Use of synthetic oligonucleotides as hybridization Probes . . . " PNAS vol. 78, No. 11 pp. 6613-6617, 1981.

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