DNA sequence encoding the tumor suppressor gene ING1

Details DNA sequence encoding the tumor suppressor gene ING1 DNA sequence encoding the tumor suppressor gene ING1

1996-11-15

2000-09-12

Brusca, John S.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 721, 435440, 435455, 4353201, 435325, 536 231, C12Q 168, C07H 2104

Patent

active

061176338

ABSTRACT:
The invention provides novel tumor suppressor genes, methods for making and using these and related tumor suppressor genes and proteins and peptides, and nucleic acids encoding these and related tumor suppressor proteins and peptides.

REFERENCES:
patent: 5217889 (1993-06-01), Roninson et al.
patent: 5580859 (1996-12-01), Felgner et al.
patent: 5589466 (1996-12-01), Felgner et al.
patent: 5811234 (1998-09-01), Roninson et al.
Berendsen H. "A Glimpse of the Holy Grail?" Science vol. 282:642-643 Oct. 1998.
Hiller et al. Database CST on MPSREN Accession No. T60958 Feb. 13, 1995.
Levine, A.J., "The Tumor Suppressor Genes", Annu. Rev. Biochem. 62:623-651 (1993).
Hunter, T. et al., "Cyclins and Cancer II: Cyclin D and CDK Inhibitors Come of Age", Cell 79:573-582 (1984).
Gudkov, A.V. et al., "Isolation of genetic suppressor elements, inducing resistance to topoisomerase II-interactive cytotoxic drugs, from human topoisomerase II cDNA", Proc. Natl. Acad. Sci USA 90:3231-3235 91993).
Straus, D. et al., "Genomic subtraction for cloning DNA corresponding to deletion mutations", Proc. Natl. Acad. Sc. USA 87:1889-1893 (1990).
Lisitsyn, N. et al., "Cloning the Differences Between Two Complex Genomes", Science 259:946-951 (1993).
Yawen, P. et al., "Down-regulation of a calmodulin-related gene during transformation of human mammary epithelial cells", Proc. Natl. Acad. Sc. USA 87:7360-7364 (1990).
Miller, A.D. et al., "Improved Retroviral Vectors for Gene Transfer and Expression", Biotechniques 7:980-986 (1989).
Serrano, M. et al., "A new regulatroy motif in cell-cycle control causing specific inhibition of cyclin D/CDK4", Nature366:704-707 (1993).
Defeo-Jones, D., "Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product", Nature 366:704-707 (1993).
Aharon, T. et al., "Selective Destabilization of Short-Lived mRNAs with the Granulocyte-Macrophage Colony-Stimulating Factor AU-Rich 3'Noncoding Region is Mediated by a Contranslational Mechanism", Mol. Cell. Biol. 13:1971-1980 (1993).
Guan, K. et al., "Growth suppression by p18, a p16.sup.INK4/MTS1 and p14.sup.INK4B/MTS2 -related CDK6 inhibitor, correlates with wild-type pRb function", Genes & Dev. 8:2939-2952 (1994).
Harper, J.W. et al., "The p21 Cdk-Interacting Protein Cip 1 is a Potent Inhibitor or G1 Cyclin-Dependant Kinases", Cell 75:805-16 (1993).
El-Deiry, W.S. et al., "WAF1, a Potential Mediator of p53 Tumor Suppression", Cell 75:817-825 (1993).
Kamb, A. et al., "A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types", Science 264:436-440 (1994).
Nobori, T. et al., "Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers", Nature 368:753-756 (1994).
Riabowol, K. et al., "The cdc2 Kinase is a Nuclear Protein that is Essential for Mitosis in Mammalian Cells", Cell 57:393-401 (1989).
Yang, Y. et al., "An approach for treating the hepatobiliary disease of cystic fibrosis by somatic gene transfer" Proc. Natl. Acad. Sci. USA 90:4601-4605 (1993).
Atadja, P. et al., "Increased activity of p53 in senescing fibroblasts" Proc. Nat'l. Acad. Sci. USA 92:8348-8352 (1995).
Grudkov, A. et al., "Cloning mammalian genes by expression selection of genetic suppressor elements: Associate of kinesin with drug resistance and cell immortalization" Proc. Nat'l. Acad. Sci. USA 91:3744-3798 (1994).
Hillier et al., (Feb. 1995), "Database EMBL Entry HS12525", WashU-EST Project .
Garkavtsev et al. (1996), "Suppression of the novel growth inhibitor p33.sup.ING1 promotes neoplastic transformation", Nature Genetics, 14(4):415-420.
Weinberg, Robert A. (1991), "Tumor Suppressor Genes", Science, 254:1138-1146.
Demetrick, D.J., "Fluorescence in situ hybridization and human cell cycle genes" In the Cell Cycle--Materials and Methods M. Pagano (ed.) Springer Verlag Press, 29-45 (1995).
Motomura et al., "Loss of alleles at loci on chromosome 13 in human primary gastric cancers" Genomics 2, 180-184 (1988).
Mitelman et al., "Report of the commitee on chromosome changes in neoplasia" Cytogenet Cell Genet 55:358-386 (1990).
Maestro et al., "Chromosome 13q deletion mapping head and neck squamous cell carcinomas: identification of two distinct regions of preferential loss" Cancer Research 56:1146-1150 (1996).
Thompson, M.E. et al., "Decreased expression of BRCA-1 accelerates growth and is often present during sporadic breast cancer progression" Nature Genetics 9:444-450 (1995).
Pear, W.S. et al., "Production of high titer helper-free retroviruses by transient transfection" Proc. Natl. Acad. Sci. 90:8392-8396 (1993).
Wong, H. et al., "Monitoring mRNA expression by polymerase chain reaction: the "primer-dropping" method" Anal. Biochem. 223:251-258 (1994).
Schneider E.L. and Fowlkes, B.J., "Measurement of a DNA content and cell volume in senescent human fibroblasts utilizing flow miltiparameter single cell analysis" Exp. Cell. Res. 98:298-302 (1976).
Tsai, L.H. et al., "The cdk2 kinase is required for the G1-to--S transition in mammalian cells" Oncogene 8:1593-1602 (1993).
Bond, et al., "Escape from senescence in human diploid fibroblasts induced directly by mutant p53" Oncogene 9:1885-1889 (1994).
Xlong et al., (1993) "p21 is a Universal Inhibitor of Cyclin Kinases", Nature, 366:701-704.

Affiliated with

Also associated with

Rating

DNA sequence encoding the tumor suppressor gene ING1 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with DNA sequence encoding the tumor suppressor gene ING1, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and DNA sequence encoding the tumor suppressor gene ING1 will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-94416