DNA sequence encoding surface protein of cryptosporidium parvum

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...

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4241511, 4242651, 4242661, 435 693, 4352523, 43525233, 4353201, 530350, 5303879, 530395, 536 235, 536 237, A61K 39002, A61K 39395, C07K 1444, C07K 1620, C12N 1530, C12N 121, C12P 2102, C12P 2108

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055914349

ABSTRACT:
Recombinant proteins have been developed for the immunization of animals against cryptosporidiosis. The Proteins are effective for the immunization of a variety of animals against Cryptosporidium parvum, particularly for the production of hyperimmune colostrum that may be used to confer passive immunity against the parasite. Isolated DNA sequences which encode these proteins have also been developed. The DNA sequences may be inserted into recombinant DNA molecules such as cloning vectors or expression vectors for the transformation of cells and the production of the proteins.

REFERENCES:
patent: 4692403 (1987-09-01), Lindner et al.
patent: 4849329 (1989-07-01), Leung et al.
patent: 5028694 (1991-07-01), Mewman et al.
patent: 5106618 (1992-04-01), Beck et al.
patent: 5229279 (1993-07-01), Peoples et al.
Kumar et al. PNAS 87:1337-1340 1990.
Bowie et al. Science 247:1306-1310 1990.
Young et al. PNAS 80:1194-1198 1983.
Reperant et al. FEMS Microbiology Letters 99:7-14 Nov. 1992.
Smith et al. Mol. Cell Biology 3(12):2156-2165 1983.
Pennock et al. Mol Cell Biology 4(3):399-406 1984.
Tizard, I. (Editor) "An Introduction to Veterinary Immunology" 2nd Edition, published by W. B. Saunders Co. 1982 (Philadelphia, Penn.) see pp. 182-188.
Petersen, Carolyn, et al., "Identification and Initial Characterization of Five Cryptosporidium parvum Sporozoite Antigen Genes", Infection and Immunity, Jun. 1992, vol. 60, No. 6, pp. 2343-2348.
Tilley, Michael, et al. "Identification of a 15-Kilodalton Surface Glycoprotein on Sporozoites of Cryptosporidium parvum", Infection and Immunity, vol. 59, No. 3, pp. 1002-1007.
Riggs, Michael W., et al., "Neutralization-Sensitive Epitopes are Exposed on the Surface of Infectious Cryptosporidium parvum Sporozoites", The Journal of Immunology, vol. 13, No. 4, Aug. 15, 1989, pp. 1340-1345.
Tilley, Michael, et al., "Cryptosporidium parvum (Apicomplexa: Cryptosporidiidae) Oocyst and Sporozoite Antigens Recognized by Bovine Colostral Antibodies", Infection and Immunity, Sep. 1990, vol. 58 No. 9, pp. 2966-2971.
Kim, Kami, et al., "Isolation, Sequence and Molecular Karyotype Analysis of the Actin Gene of Cryptosporidium parvum", Molecular and Biochemical Parasitology, 50(1192), pp. 105-114.
Nelson, Richard G., et al., "Identification and Isolation of Cryptosporidium parvum Genes Encoding Microtubule and Microfilament Proteins", Journal of Protozoology, vol. 38, No. 6, Nov.-Dec. 1991, pp. 52S-55S.
Jenkins, M. C., et al., "Molecular cloning and Characterization of cDNA Encoding a 15 kDA Cryptosporidium parvum Surface Protein", The American Society of Parasitologists 67th Annual Meeting Program and Abstracts, The Univ. of Pennsylvania, Philadelphia, PA, Aug. 4-8, 1992.
Fayer, R., et al., "Hyperimmune Bovine Colostrum Neutralizes Cryptosporidium Sporozoites and Protects Mice Against Oocyst Challenge", The Journal of Parasitology, vol. 75, No. 1, Feb. 1989, pp. 151-153.
Fayer, R., et al., "Efficacy of Hyperimmune Bovine Colostrum for Prophylaxis of Cryptosporidiosis in Neonatal Calves", The Journal of Parasitologists, vol. 75, No. 3, Jun. 1989, pp. 393-397.
Laxer, Marc A., et al., "DNA Sequences for the Specific Detection of Cryptosporidium parvum by the Polymerase Chain Reaction", Am. J. Trop. Med. Hyg., 45(6), 1991, pp. 688-694.
Gooze, Lisa, et al., "Amplification of a Cryptosporidium parvum Gene Fragment Encodign Thymidylate Synthase", J. Protozool., vol. 38, No. 6, Nov.-Dec., 1991, pp. 56S-58S.
Fayer, R., "Immunogold Labeling of States of Cryptosporidium parvum Recognized by Immunoglobins in Hyperimmune Bovine Colostrum", J. Parasitol, 77(3) 1991, pp. 487-490.

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