DNA sequence encoding nonglycosylated analogs of human colony st

Details DNA sequence encoding nonglycosylated analogs of human colony st DNA sequence encoding nonglycosylated analogs of human colony st

1988-10-24

1995-04-11

Ellis, Joan

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 695, 435 699, 4351723, 4353201, 4352351, 4352523, 530350, 935 10, 935 28, 935 56, 935 61, 935 69, C07H 1512, C12P 2102, C12P 1934, C12N 1500, C12N 700, C12N 121, C12N 116, C12N 118, C07K 300

Patent

active

054059526

ABSTRACT:
An analog human colony stimulating factor (hCSF) is disclosed, comprising a mutant amino acid sequence which is substantially homologous to the native sequence of an hCSF having at least one N-glycosylation site, wherein the mutant sequence comprises at least one amino acid substitution, deletion or insertion inactivating the N-glycosylation site.

REFERENCES:
patent: 4546082 (1985-10-01), Kurjan et al.
patent: 4876197 (1989-10-01), Burke et al.
patent: 4877729 (1989-10-01), Clark et al.
Cantrell et al., "Cloning, Sequence, and Expression of a Human Granulocyte/Macrophage Colony Stimulating Factor," Proc. Natl. Acad. Sci. 82:6250 (1985).
Wong et al., "Human GM-CSF: Molecular Cloning of the Complementary DNA and Purification of the Natural and Recombinant Proteins," Science 228:810 (1985).
Lee et al., "Isolation of cDNA for a Human Granulocyte-Macrophage Colony Stimulating Factor by Functional Expression in Mammalian Cells," Proc. Natl. Acad. Sci. 82:4360 (1985).
Miyajima et al., "Expression of Murine and Human Granulocyte Macrophage Colony Stimulating Factors in S. cerevisiae: Mutagenesis of the Potential Glycosylation Sites," EMBO 5:1193 (1986).
Kawasaki et al., "Molecular Cloning of a Complementary DNA Encoding Human Macrophage Specific Colony Stimulating Factor (CSF-1)," Science 230:291 (1985).
Gasson et al., "Molecular Characterization and Expression of the Gene Encoding Human Erythroid-Potentiating Activity," Nature 315:768 (1985).
Yang et al., "Human IL-3 (Multi-CSF): Identification by Expression Cloning of a Novel Hematopoietic Growth Factor Related to Murine IL-3," Cell 47:3 (1986).
Donahue, et al Cold Spring Harbor Symposia on Quantitative Biology, vol. LI, CSH Laboratory, N.Y. (1986) (Meeting Date-Jun. 1986).
Valenzuela et al Nature vol. 298 pp. 347-350 (1982).

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