DNA sequence encoding human cystathionine .beta.-synthase

Details DNA sequence encoding human cystathionine .beta.-synthase DNA sequence encoding human cystathionine .beta.-synthase

1993-09-13

1996-06-04

Wax, Robert A.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

4351723, 4353201, 4352523, 43525233, 435232, 536 232, C12N 510, C12N 121, C12N 119, C12N 1560, C12N 1563

Patent

active

055232256

ABSTRACT:
Disclosed is a purified and isolated DNA sequence encoding human cystathionine .beta.-synthase. Also disclosed is a purified and isolated human cystathionine .beta.-synthase encoded by this DNA sequence. Included is a composition of human cystathionine .beta.-synthase in a pharmacologically acceptable carrier for treating a human suffering from homocystinuria. Also provided are methods of screening human patients to detect mutations in the cystathionine .beta.-synthase gene.

REFERENCES:
patent: 4965188 (1990-10-01), Mullis et al.
Kraus (1990) in "Molecular Genetics of Chromosome 21 and Down Syndrome", eds. Patterson et al. New York: Wiley-Liss, Inc., pp. 201-214.
Kraus (1987) Methods in Enzymology 143: 388-394.
Skovby et al. (1984) Am. J. Hum. Genet.36: 452-459.
Kozich et al. 1992 Human Mutation 1 (2) 113-123.
Wahl et al. (1987) Methods in Enzym. 152: 415-423.
Kraus et al (1993) Human Mol. Genet. 2 1633-1638.
Micrendorf et al (1987) Methods in Enzym. 152 458-469.
Griffiths et al. (1977) Eur. J. Biochem.
Kraus et al (1986) Proc. Nat. Acad Sci, USA 83: 2047-2051.
Skovby et al. (1984) J. Biol. Chem. 259: 583-587.
Krauz et al (1990) Proc. Nat. Acad. Sci. USA 87: 6629-6633.
Ono et al (1988) J. Bacteriol. 170:5883-5889.
Frohman et al. (1988) Proc. Nat. Acad Sci, USA. 85: 8998-9002.
Ono et al (1992) Current Genet. 21 285-289.

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