DNA sequence encoding Factor VII with an amino acid substitution

Details DNA sequence encoding Factor VII with an amino acid substitution DNA sequence encoding Factor VII with an amino acid substitution

1992-09-21

1994-02-22

Weimar, Elizabeth C.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

536 231, 935 10, C12N 500, C12N 1500, C07H 1512, C07H 1700

Patent

active

052886298

ABSTRACT:
Factor VII of the coagulation cascade is modified to act as an anticoagulant. Amino acid modifications are employed to produce a modified Factor VII having a substantially reduced susceptibility to activation by enzymes which typically activate wild-type Factor VII. The modified Factor VII is able to compete with wild-type Factor VII and/or VIIa for binding tissue factor, inhibiting clotting activity. As the modified Factor VII acts specifically to interrupt the coagulation cascade, pharmaceutical compositions of modified Factor VII may be administered in place of, or in conjunction with lower doses of, conventional anticoagulant therapies.

REFERENCES:
patent: 4775624 (1988-10-01), Bang et al.
patent: 4784950 (1988-11-01), Hagen
patent: 4959318 (1990-09-01), Foster et al.
patent: 4994371 (1991-02-01), Davie et al.
Lee et al. (1983) Thromb. Res. 30, 511-519.
Hagen et al. (1986) PNAS 83, 2412-2416.
Pittman et al. (1988) PNAS 85, 2429-2433.
Kisiel et al., Biochem. 16:4189-4194 (1977).
Petersen et al., FEBS Lett. 114:278-282 (1980).
McRae et al., Biochem. 20:7196-7206 (1981).
Hojrup et al. (Eur. J. Biochem.) 126:343-348 (1982).
Lottenberg et al., Thromb. Res. 28:313-332 (1982).
Broze et al. (J. Clin. Invest.) 73:933-938 (1984).
Cho et al., Biochem. 23:644-650 (1984).
Leytus et al., Biochem. 25:5098-5102 (1986).
Foster et al., Biochem. 26:7003-7011 (1987).
Thim et al., Biochem. 27:7785-7793 (1988).
Sakai et al., J. Biol. Chem. 264:9980-9988 (1989).
Kurachi et al., Proc. Natl. Acad. Sci. USA, 79:6461-6464 (1982).
Degen et al., Am. Chem. Soc., 22:2087-2097 (1983).
Leytus et al., Proc. Natl. Acad. Sci. USA, 81:3699-3702 (1984).
Foster et al., Proc. Natl. Acad. Sci. USA, 82:4673-4677 (1985).
Takeya et al., J. Biol. Chem., 263:14868-14872 (1988).

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