Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1992-04-10
1994-01-18
Hill, Jr., Robert J.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
424 858, 53038822, 530399, 435 6, 4352402, 435 694, 4353201, 536 2431, C07H 1512, A61K 3738, A61K 3724, C12Q 100
Patent
active
052801128
ABSTRACT:
The present invention relates to a mammalian adrenocorticotropic hormone receptor. The invention is directed toward the isolation, characterization and pharmacological use of mammalian adrenocorticotropic hormone receptor, the gene corresponding to this receptor, a recombinant eukaryotic expression construct capable of expressing a mammalian adrenocorticotropic hormone receptor in cultures of transformed eukaryotic cells and such cultures of transformed eukaryotic cells that synthesize mammalian adrenocorticotropic hormone receptor. The invention also provides methods for screening ACTH.sup.R agonists and antagonists in vitro using preparations of receptor from such cultures of eukaryotic cells transformed with a recombinant eukaryotic expression construct comprising the ACTH.sup.R receptor gene. The invention specifically provides human and bovine ACTH.sup.R genes.
REFERENCES:
Hanneman et al., in Peptide Hormone as Prohormones, G. Martinez, ed. (Ellis Horwood Ltd.: Chichester, UK) pp. 53-82.
DeWied & Jolles, 1982, Physiol. Rev. 62:976-1059.
Oelofsen & Ramachandran, 1983, Arch. Biochem. Biophys. 225:414-421.
Mertz & Catt, 1991, Proc. Natl. Acad. Sci. USA 88:8525-8529.
Moore et al., 1991, Endocrinology 34:107-114.
Cone Roger D.
Mountjoy Kathleen G.
Hill Jr. Robert J.
State of Oregon, Oregon Health Sciences University
Wang Gian P.
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