DNA sequence encoding active fragment of fibroblast growth facto

Details DNA sequence encoding active fragment of fibroblast growth facto DNA sequence encoding active fragment of fibroblast growth facto

1990-11-23

1993-04-27

Hill, Jr., Robert J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

530324, 530350, 530399, 336 2351, C12N 1500, C12N 1518, C12N 1519

Patent

active

052063542

ABSTRACT:
The present invention relates to novel fragments of basic fibroblast growth factor (bFGF). The mitogenic potency of one of these bFGF fragments, identified as HBF-2 is about 25-50 fold less than that of native bFGF but at least 10.sup.3 -10.sup.4 fold more active than that of previously reported synthetic fragments of bFGF. Therefore, the present invention provides the shortest fragment of bFGF that retains substantial biologic activity.

REFERENCES:
Abraham, J. A. et al., EMBO Journal, 5(10):2523-2528, 1986.
Baldin, V. et al., EMBO Journal, 9(5):1511-1517, 1990 (May).
Ornitz, D. M., Moll Cell. Biol., 12:240-247, 1992.
Vlodavsky, I., TIBS, 16:268-271, 1991.
Presta, M., J. Cell. Physiology, 149:512-524, 1991.
Imamura, T., Science, 249:1567-1570, 1990 (Sep.).
Isaachi, A., PNAS, 88:2628-32, 1991.
Burgess, W. H. et al., J. Cell. Biochemistry, 45:131-138, 1991.
Baird, A. et al., PNAS, 85:2324-2328, 1988 (Apr.).
Seno, M. et al., Eur. J. Biochem., 188:239-45, 1990 (Mar.).

Affiliated with

Also associated with

Rating

DNA sequence encoding active fragment of fibroblast growth facto does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with DNA sequence encoding active fragment of fibroblast growth facto, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and DNA sequence encoding active fragment of fibroblast growth facto will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2328431