DNA sequence encoding a polypeptide with anti-tumor properties

Details DNA sequence encoding a polypeptide with anti-tumor properties DNA sequence encoding a polypeptide with anti-tumor properties

1993-10-29

1996-08-06

Wax, Robert A.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

5303879, 5303881, C07K 100, C07K 1600, C12P 2108

Patent

active

055434991

ABSTRACT:
The invention relates to the DNA sequence encoding the AUF1 polypeptide, or fragments thereof. Also, the invention relates to the AUF1 polypeptide itself or fragments thereof. Methods are disclosed for detecting the severity of neoplastic transformation. Methods are disclosed for detecting pharmacologicals that enhance the anti-tumor activity of AUF1. Methods are disclosed for treating a patient with a low level of the AUF1 gene.

REFERENCES:
patent: 5354847 (1994-10-01), Liu et al.
patent: 5444149 (1995-08-01), Keene et al.
Brewer Mol. and Cell Biol. vol. 11 pp. 2460-2466 May 1991.
Rasheed, et al. (1992) Genes, Chromosomes & Cancer 5:75-82.
Harris, et al. (1992) Blood 79(12):3316-3324.
Zhang, et al. (1993) Mol. Cell. Biol. 13(12):7652-7665.

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