Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1989-06-29
1991-12-17
Schwartz, Richard A.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C07H 1512
Patent
active
050736094
ABSTRACT:
Genomic and cDNA sequences coding for a protein having substantially the same biological activity as human protein C are disclosed. Recombinant plasmids and bacteriophage transfer vectors incorporating these sequences are also disclosed.
REFERENCES:
patent: 4775624 (1988-10-01), Bang et al.
patent: 4784950 (1988-11-01), Hagen et al.
patent: 4968626 (1990-11-01), Foster et al.
J. H. Griffin et al., "Deficiency of Protein C in Congenital Thrombotic Diseases", J. Clin. Invest. 68:1370-1373, 1981.
W. Kisiel, "Human Plasma Protein C", J. Clin. Invest. 64:761-769, 1979.
V. W. M. van Hisbergh et al., "Activated Protein C Decreases Plasminogen Activator-Inhibitor Activity in Endothelial Cell-Conditioned Medium", Blood 65:444-451, Feb. 1985.
W. Kisiel et al., "Enzymological Aspect of Blood Coagulation", Behring Inst. Mitt. 73:29-42, 1983.
J. E. Gardiner and J. H. Griffin, "Human Protein C and Thromboembolic Disease", Progress in Hematology, 265-278, 1983.
Philip C. Comp et al., "Generation of Fibrinolytic Activity by Infusion of Activated Protein C into Dogs", J. Clin. Invest. 68:1221-1228, 1981.
Y. Sakata et al., "Activated Protein C Stimulates the Fibrinolytic Activity of Cultured Endothelial Cells and Diseases Antiactivator Activity", Proc. Acad. Sci. USA 82:1121-1125, 1985.
A. Broekmans et al., "Congenital Protein C Deficiency and Venous Thromboembolism", The New England Journal of Medicine 309:340-344, 1983.
U. Seligsohn et al., "Homozygous Protein C Deficiency Manifested by Massive Venous Thrombosis in the Newborn", The New England Journal of Medicine 310:559-562, 1964.
R. A. Marlar, "Mechanism of Action of Human Activated Protein C, a Thrombin-Dependent Anticoagulant Enzyme", Blood 59:1067-1072, 1982.
Kisiel and Davie, "Protein C", Methods in Enzymology 80:320-332, 1981.
Miletich and Broze, "Characterization of Monoclonal Antibody Specific for the Heavy Chain of Non-Activated Human Protein C", Thrombosis 305a:1123, Nov. 1983.
Esmon et al., "Identification of an Encothelial Cell Cofactor for Thrombin-Catalyzed Activation of Protein C", Proc. Natl. Acad. Sci. (USA) 78:2249-2252, 1981.
Kisiel et al., "Anticoagulant Properties of Bovine Plasma Protein C Following Activation by Thrombin", Biochem. 16:5824-5831, 1977.
Long et al., "Cloning and Sequencing of Liver cDNA Coding for Bovine Protein C", Proc. Natl. Acad. Sci. (USA) 81:5653-5656, 1984.
Walker et al., "The Inhibition of Blood Coagulation by Activated Protein C through the Selective Inactivation of Activated Factor V", Biochim. et Biophys. Acta 571:333-342, 1979.
Katayama et al., "Comparison of Amino Acid Sequence of Bovine Coagulation Factor IX (Christman Factor) with that of Other Vitamin K-Dependent Plasma Proteins", Proc. Natl. Acad. Sci. (USA) 76:4990-4994, 1979.
Kaufman and Sharp, "Construction of a Modular Dihydrofolate Reductase cDNA Gene: Analysis of Signals Utilized for Efficient Expression", Mol. and Cell. Biol. 2:1304-1319, 1982.
Kaufman, "Identification of the Components Necessary for Adenovirus Translational Control and their Utilization in cDNA Expression Vectors", Proc. Natl. Acad. Sci (USA) 82:689-693, 1985.
Hermonat et al., "Use of Adeno-Associated Virus as a Mammalian DNA Cloning Vector: Transduction of Neomycin Resistance into Mammalian Tissue Culture Cells", Proc. Natl. Acad. Sci. (USA) 81:6466-6470, 1984.
McMullen et al., "The Occurrence of -Hydroxyaspartic Acid in the Vitamin K-Dependent Blood Coagulation Zymogens", Biochem. and Biophys. Res. Comm. 115:8-14, 1983.
Ginsburg et al., "Human von Willebrand Factor (vWF): Isolation of Complementary DNA (cDNA) Clones and Chromosomal Localization", Science 228:1401-1406, 1985.
Davie Earl W.
Foster Donald C.
Cook Dian
Schwartz Richard A.
The Board of Regents of the University of Washington
LandOfFree
DNA sequence coding for protein C does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with DNA sequence coding for protein C, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and DNA sequence coding for protein C will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-836159