DNA sequence and encoded polypeptide useful in the diagnosis of

Details DNA sequence and encoded polypeptide useful in the diagnosis of DNA sequence and encoded polypeptide useful in the diagnosis of

1992-02-04

1995-08-01

Scheiner, Toni R.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

530324, 4241891, 436820, 436518, 436526, C07K 14005, G01N 3353

Patent

active

054379741

ABSTRACT:
A novel cDNA clone, 20E, has been isolated and characterized as encoding a previously unknown polypeptide antigen recognized by antibodies in the serum of certain patients with non-A non-B hepatitis (NANBH). The nucleic acid sequence is not represented in the genome of the Hepatitis C Virus (HCV). Neither is the nucleic acid sequence represented in the human genome. The data suggest that the RNA sequence corresponding to clone 20E is contained within the genome of an external infective agent other than HCV, and therefore may represent an additional etiologic agent or contributing factor to the development of NANBH in human patients. The 20E nucleic acid and corresponding polypeptide and respective variants thereof will be useful in a variety of procedures directed at prevention and diagnosis of NANBH.

REFERENCES:
patent: 5106726 (1992-04-01), Wang
Merrifield, R. B., Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide. J. Am. Chem. Soc. 85:2149-2154, 1963.
Hollinger, "Non-A, Non-B Hepatitis Viruses," Virology (2nd ed.) 2239-73 (B. N. Fields et al., Eds. Raven Press, N.Y. 1990).
Arima et al., "Cloning of a cDNA associated with acute and chronic hepatitis C infection generated from patients serum RNA," Gastroenterol. Jpn. 24:540 (1989).
Arima et al., "A lambda gt11-cDNA clone specific for chronic hepatitis C generated from pooled serum presumably infected by hepatitis C virus," Gastroenterol. Jpn. 24:545 (1989).
Arima et al., "Cloning of serum RNA associated with hepatitis C infection suggesting heterogeneity of the agent(s) responsible for the infection," Gastroenterol. Jpn. 24:685 (1989).
Arima et al., "A cDNA clone encoding a peptide highly specific for hepatitis C infection," Gastroenterol. Jpn. 25:218 (1990).

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