DNA sequence

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...

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414 858, 514 8, 530387, 530389, 530390, 530391, 536 27, 536 28, 536 29, 935 15, C07H 1910, C07H 1920, C07H 2102, C07H 2104

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047867191

ABSTRACT:
A DNA sequence comprising a polynucleotide segment consisting of a DNA sequence (A) shown below and a DNA sequence complementary thereto: ##STR1## wherein A represents deoxyadenosine-5'-phosphate, C represents deoxycytidine-5'-phosphate, G represents deoxyguanosine-5'-phosphate, and T represents deoxythymidine-5'-phosphate.
The DNA sequence provided by this invention is derived from a rearranged immunoglobulin heavy chain variable (V.sub.H) region gene taken from the mouse hybridoma NL-1 cells which produce an antibody capable of commonly recognizing surface antigens of various human acute lyphocytic leukemia cells. Accordingly, if, for example, it is combined with a heavy chain constant (C.sub.H) region gene, a heavy chain can be produced which can recognize commonly various human acute lymphocytic leukemia cells in combination with a proper light chain. This would serve for the diagnosis and treatment of human acute lymphocytic leukemia.

REFERENCES:
Kudo et al, (I), J. Immunology, vol. 135, pp. 642-645, 1985 (Jul.).
Brodeur et al., European J. Immunology, vol. 14, pp. 922-930, 1984.
Xancopolous et al., Nature, vol. 311, pp. 727-733, 1984.
Kudo et al, (II), Gene, vol. 33, pp. 181-189, 1985 (Apr. '85).

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