Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1985-10-24
1988-11-22
Brown, J. R.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
414 858, 514 8, 530387, 530389, 530390, 530391, 536 27, 536 28, 536 29, 935 15, C07H 1910, C07H 1920, C07H 2102, C07H 2104
Patent
active
047867191
ABSTRACT:
A DNA sequence comprising a polynucleotide segment consisting of a DNA sequence (A) shown below and a DNA sequence complementary thereto: ##STR1## wherein A represents deoxyadenosine-5'-phosphate, C represents deoxycytidine-5'-phosphate, G represents deoxyguanosine-5'-phosphate, and T represents deoxythymidine-5'-phosphate.
The DNA sequence provided by this invention is derived from a rearranged immunoglobulin heavy chain variable (V.sub.H) region gene taken from the mouse hybridoma NL-1 cells which produce an antibody capable of commonly recognizing surface antigens of various human acute lyphocytic leukemia cells. Accordingly, if, for example, it is combined with a heavy chain constant (C.sub.H) region gene, a heavy chain can be produced which can recognize commonly various human acute lymphocytic leukemia cells in combination with a proper light chain. This would serve for the diagnosis and treatment of human acute lymphocytic leukemia.
REFERENCES:
Kudo et al, (I), J. Immunology, vol. 135, pp. 642-645, 1985 (Jul.).
Brodeur et al., European J. Immunology, vol. 14, pp. 922-930, 1984.
Xancopolous et al., Nature, vol. 311, pp. 727-733, 1984.
Kudo et al, (II), Gene, vol. 33, pp. 181-189, 1985 (Apr. '85).
Ichikawa Yataro
Kudo Akira
Nishimura Yushi
Watanabe Takeshi
Brown J. R.
Crane L. Eric
Teijin Limited
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