Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1989-12-01
1993-02-02
Moskowitz, Margaret
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 231, 4352523, 4353201, C07H 1512, C12N 120, C12N 1500
Patent
active
051838842
ABSTRACT:
A DNA fragment distinct from the epidermal growth factor receptor (EGF-R) and erbB-2 genes was detected by reduced stringency hybridization of v-erbB to normal genomic human DNA. Characterization of the cloned DNA fragment mapped the region of v-erbB homology to three exons with closest homology of 64% and 67% to a contiguous region within the tyrosine kinase domains of the EGF-R and erbB-2 proteins, respectively. cDNA cloning revealed a predicted 148 kd transmembrane polypeptide with structural features identifying it as a member of the erbB family, prompting designation of the new gene as erbB-3. It was mapped to human chromosome 12q11-13 and was shown to be expressed as a 6.2 kb transcript in a variety of normal tissues of epithelial origin. Markedly elevated erbB-3 mRNA levels were demonstrated in certain human mammary tumor cell lines. These findings indicate that increased erbB-3 expression, as in the case of EGF-R and erbB-2, plays a role in some human malignancies.
REFERENCES:
Anti-erbB MaBs : hybridomas HB 9097 & HB 9098, ATCC Catalog 7th edn., 1992, p. 415.
Coussens et al., Science 230:1132-1139 (Dec. 6, 1985).
Improved Tools for Biological Sequence Comparison-William R. Pearson and David J. Lipman.
Signal Transduction Through the EGF Receptor Transfected in Il-3-Dependent Hematopoietic Cells-Jacalyn H. Pierce, Marco Ruggiero, Timothy P. Fleming, Pier Paolo Di Fiore, Joel S. Greenberger, Lyubra Varticovski, Joseph Schlessinger Giovannia Rovera, and Stuart A. Aaronson.
Overexpression of the EGF Receptor-Related Proto-Oncogene erbB-2 in Human Mammary Tumor Cell Lines by Different Colecular Mechanisms-Matthias H. Kraus, Nicholas C. Popescu, Suzanne C. Amsbaugh and C. Richer King.
Amplification of a Novel v-erB-related gene in a human mammary carcinoma. King, Kraus and Aaronson. Science, vol. 229 Sep. 6, 1985.
Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor. Yamamoto, Ikawa, Akiyama, Semba, Nomura, Miyajima, Saito and Toyoshima. Nature vol. 319 Jan. 16, 1986.
erb-2 Is a Potent Oncogene When overexpressed in NIH/3T3 Cells. Di Fiore, Pierce, Kraus, Segatto, King and Aaronson. Science, vol. 237 Jul. 10, 1987.
Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: Evidence for overexpression in a subset of human mammary tumors. M. Kraus, W. Issing, T. Miki, N. Popescu and S. Aaronson; Proc. Natl. Acad. Sci. USA vol. 86, pp. 9193-9197, Dec. 1989 Biochemistry.
A v-erbB-related protooncogene, c-erbB-2, is distinct from the c-erbB-1/epidermal growth factor-receptor gene is amplified in a human salivary gland adenocarcinoma. K. Semba, N. Kamata, K. Toyoshima and T. Yamamoto Proc. Natl. Acad. Sci., USA vol. 82, pp. 6497-6501, Oct. 1985 Biochemistry.
Aaronson Stuart A.
Kraus Matthias H.
Moskowitz Margaret
United States of America
Zitomer Stephanie W.
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