DNA-reporter conjugates linked via the 2' or 5'-primary amino gr

Details DNA-reporter conjugates linked via the 2' or 5'-primary amino gr DNA-reporter conjugates linked via the 2' or 5'-primary amino gr

1991-02-27

1992-06-02

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 28, 536 29, C07H 2100, C07H 2104

Patent

active

051188023

ABSTRACT:
The invention consists of compounds and methods for the synthesis of oligonucleotides which contain one or more free aliphatic amino groups attached to the sugar moieties of the nucleoside subunits. The synthetic method is versatile and general, permitting amino groups to be selectively placed at any position on oligonucleotides of any composition or length which is attainable by current DNA synthetic methods. Fluorescent dyes or other detectable moieties may be covalently attached to the amino groups to yield the corresponding modified oligonucleotide.

REFERENCES:
patent: 3906031 (1975-09-01), Carpino et al.
patent: 4373071 (1983-02-01), Itakura
patent: 4401796 (1983-08-01), Itakura
patent: 4415732 (1983-11-01), Caruthers et al.
patent: 4757141 (1988-07-01), Fung et al.
Chu et al., Nucl. Acids Res, 11:6513-6529, 1983.
Langer et al., Proc. Natl. Acad. Sci U.S.A. 78(11): 6633-6637 (1981).
Draper et al., Biochemistry 19: 1774-1781, 1980.

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