Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1995-03-27
1998-01-13
Chambers, Jasemine C.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 691, 4351723, 4353201, 536 241, 935 8, 935 39, 935 41, C12Q 168, C07H 2104, C12N 1511, C12N 1567
Patent
active
057078033
ABSTRACT:
The present invention provides oligonucleotide sequences comprising DNA regulatory elements comprising point mutations of Ly6E GAS element that bind activated transcriptional regulatory proteins in response to signaling molecules, such as cytokines. Further, the present invention also provides DNA constructs comprising the oligonucleotide sequences, cells transfected with the DNA constructs, and methods of using the DNA constructs and transfected cells to provide for the controlled expression of structural genes, for the detection and recovery of transcriptional regulatory proteins, and for measuring the ability of compounds to act as agonist and antagonists of gene transcription.
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Lamb Ian Peter
Seidel H. Martin
Chambers Jasemine C.
Elmer J. Scott
Ligand Pharmaceuticals Inc.
Priebe Scott D.
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