DNA probe which reveals a hypervariable region on human chromoso

Details DNA probe which reveals a hypervariable region on human chromoso DNA probe which reveals a hypervariable region on human chromoso

1990-10-05

1992-01-28

Wax, Robert A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, 4351723, 436501, 935 78, C12Q 168, C07H 2104

Patent

active

050845667

ABSTRACT:
A DNA probe pl-79 is homologous to at least a portion of a hypervariable DNA region located at chromosome lp36.3 in the human genome. The DNA region displays extensive restriction fragment length polymorphisms when digested with certain restriction endonucleases. Probe pl-79 is believed to have a repeated 39 base sequence CCTGGGGGTGNGNGTGCTGTTCCAGGCTGTCAGAGGCTC, and can be used as a genetic "fingerprint" to establish human identity, determine engraftment of bone marrow transplants, determine parentage, and otherwise map genes.

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White, R. et al., (1986) in DNA Probes, Applications in Genetic and Inf. Disease and Cancer, (Ed. L. S. Lerman, Cold Spring Harbor Labs, Cold Spring Harbor, N. Y.) pp. 43-47.
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Jeffreys et al., "Individual-specific `fingerprints` of human DNA", Nature, 316:76-79 (1985).
Buroker et al., "A hupervariable DNA region on human chromosome lp", Genetics, 113:PT2 (Supp. 1986).
Nakamura et al., "Characterization of a human `midisatellite` sequence", Nucleic Acids Research, 15:2537-2547 (1987).

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