DNA probe which reveals a hypervariable region on human chromoso

Details DNA probe which reveals a hypervariable region on human chromoso DNA probe which reveals a hypervariable region on human chromoso

1988-08-30

1991-12-31

Wax, Robert A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, 435 91, 436501, 935 77, 935 78, C07H 2104, C12Q 168

Patent

active

050774000

ABSTRACT:
A DNA probe p144-D6 is homologous to at least a portion of a hypervariable DNA region located on chromosome 17(17p13) in the human genome. The DNA region displays a restriction fragment length polymorphism when digested with certain restriction endonucleases. Unrelated invididuals often display unique fragment patterns on Southern blots probed with p144-D6. The probe can be used to produce a genetic "fingerprint" for establishing human identity, determining engraftment of bone marrow transplants, determining parentage, and otherwise mapping genes.

REFERENCES:
patent: 4302204 (1981-11-01), Wahl et al.
patent: 4358535 (1982-11-01), Falkow et al.
patent: 4399216 (1983-08-01), Axel et al.
patent: 4468464 (1984-08-01), Cohen et al.
patent: 4594318 (1986-06-01), Gusella et al.
patent: 4599303 (1986-07-01), Yabusaki et al.
patent: 4623619 (1986-11-01), Owerbach et al.
Jeffreys et al., "Individual-Specific `Fingerprints` of Human DNA", Nature 316:76-79 (1985).
Wyman and White, "A Highly Polymorphic Locus in Human DNA", Proc. Natl. Acad. Sci. U.S.A., 77:6754-6758 (1980).
Nakamura et al., "Characterization of a Human `Midisatellite` Sequence", Nucl. Acids Res. 15:2537-2547 (1987).
Buroker et al., "A Hypervariable DNA Region on Human Chromosome 1p", Genetics 113:Supplement No. 1, part 2, p. 564 (1986).
Litt et al., "A Highly Polymorphic Locus in Human DNA Revealed by Probes from Cosmid 1-5 Maps to Chromosome 2q35.fwdarw.37", Am. J. Hum. Genet. 38:288-296 (1986).
Litt and White, "A Highly Polymorphic Locus in Human DNA Revealed by Cosmid-Derived Probes", Proc. Natl. Acad. Sci. U.S.A., 82:6206-6210 (1985).
Bufton et al., "Four Restriction Fragment Length Polymorphisms Revealed by Probes from a Single Cosmid Map to Chromosome 19", Am. J. Hum. Genet., 38:447-460 (1986).
Buroker et al., "A Hypervariable Region at the D19S11 Locus", Hum. Genet., 76:90-95 (1987).
Bufton et al., "A Highly Polymorphic Locus on Chromosome 16q Revealed by a Probe from a Chromosome-Specific Cosmid Library", Hum. Genet., 74:425-431 (1986).

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