DNA probe which reveals a hypervariable region on human chromoso

Details DNA probe which reveals a hypervariable region on human chromoso DNA probe which reveals a hypervariable region on human chromoso

1987-05-27

1990-12-25

Yarbrough, Amelia Burgess

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, 4351723, 436501, 935 9, 935 19, 935 23, 935 78, 935 79, 935 80, C07H 2100, C12Q 168, G01N 3348, G01N 3353

Patent

active

049804618

ABSTRACT:
A DNA probe which is homologous to at least a portion of a hypervariable DNA region D2S3 located at chromosome 2q35-37 in the human genome. The DNA region displays restriction fragment length polymorphism when digested with certain restriction endonucleases. The probe, p5-1-25, can be used to produce a genetic "fingerprint" to establish human identity, determine engraftment of bone marrow transplants, determine parentage, and otherwise map genes.

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Jeffreys et al., "Individual-Specific `Fingerprints` of Human DNA", Nature, 316:76-79 (1985).
Buroker et al., "A Hypervariable DNA Region on Human Chromosome lp", Genetics, 113:PT2 (Supp. 1986).
Nakamura et al., "Characterization of Human `Midisatellite` Sequence", Nucleic Acids Research, 15:2537-2547 (1987).
Litt et al., "A Highly Polymorphic Locus in Human DNA Revealed by Cosmid-Derived Probes", Proc. Natl. Acad. Sci., 82:6206-6210 (1985).
Litt et al., "A Highly Polymorphic Locus in Human DNA Revealed by Probes from Cosmid 1-5 Maps to Chromosome 2g35.fwdarw.37", Am. H. Hum. Genet., 38:288-296 (1986).

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