DNA probe which reveals a hypervariable region on human chromoso

Details DNA probe which reveals a hypervariable region on human chromoso DNA probe which reveals a hypervariable region on human chromoso

1987-09-30

1991-06-25

Wax, Robert A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 6, 4351723, 436501, 935 78, C07H 2104, C12Q 168

Patent

active

050268376

ABSTRACT:
A DNA probe p79-2-23 is homologous to at least a portion of a hypervariable DNA region located on chromosome 16q22.fwdarw.q24 in the human genome. The DNA region displays a restriction fragment length polymorphism when digested with certain restriction endonucleases. Unrelated individuals display unique fragment patterns on Southern blots probed with p79-2-23. The probe can be used to produce a genetic "fingerprint" for establishing human identity, determining engraftment of bone marrow transplants, determining parentage, and otherwise mapping genes.

REFERENCES:
patent: 4302204 (1981-11-01), Wahl et al.
patent: 4358535 (1982-11-01), Falkow et al.
patent: 4399216 (1983-08-01), Axel et al.
patent: 4468464 (1984-08-01), Cohen et al.
patent: 4594318 (1986-06-01), Gusella et al.
patent: 4599303 (1986-07-01), Yabusaki et al.
patent: 4623619 (1986-11-01), Owerbach et al.
Jeffreys et al., "Individual-Specific `Fingerprints` of Human DNA," Nature 316:76-79 (1985).
Wyman and White, "A Highly Polymorphic Locus in Human DNA," Proc. Natl. Acad. Sci., U.S.A., 77:6754-6758 (1980).
Nakamura et al., "Characterization of a Human `Midisatellite` Sequence," Nucl. Acids Res., 15:2537-2547 (1987).
Buroker et al., "A Hypervariable DNA Region on Human Chromosome 1p," Genetics, 113: Supplement No. 1, Part 2, p. S64 (1986).
Litt et al., "A Highly Polymorphic Locus in Human DNA Revealed by Probes from Cosmid 1-5 Maps to Chromosome 2q35-37," Am. J. Hum. Genet., 38:288-296 (1986).
Litt & White, "A Highly Polymorphic Locus in Human DNA Revealed by Cosmid-Derived Probes," Proc. Natl. Acad. Sci. U.S.A., 82:6206-6210 (1985).
Bufton et al., "Four Restriction Fragment Length Polymorphisms Revealed by Probes from a Single Cosmid Map to Chromosome 19," Am. J. Hum. Genet., 38:447-460 (1986).
Buroker et al., "A Hypervariable Region at the D19S11 Locus," Hum. Genet., 76:90-95 (1987).
Bufton et al., "A Highly Polymorphic Locus on Chromosome 16q Revealed by a Probe from a Chromosome-Specific Cosmid Library," Hum. Genet., 74:425-431 (1986).
White et al. (1986) in DNA Probes, Applications in Genetic and Inf. Disease and Cancer (Ed. L. S. Lerman, Cold Spring Harbor Labs., Cold Spring Harbor, N.Y.), pp. 43-47.
Darby et al. (1986), Nucleic Acids Research, vol. 14, No. 23, p. 9543.

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