DNA preparation of Christmas factor and use of DNA sequences

Details DNA preparation of Christmas factor and use of DNA sequences DNA preparation of Christmas factor and use of DNA sequences

1989-05-19

1991-02-19

Lee, Lester L.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

536 27, 4353201, 435 11, 4351723, 435243, 935 1, 935 2, 935 6, 935 8, 935 9, 935 11, 935 12, 935 23, 935 29, 935 56, 935 62, 935 78, 935 80, 935 81, 436501, 436504, C12Q 168, C12N 1512

Patent

active

049943715

ABSTRACT:
There is disclosed an isolated DNA sequence and the amino acid sequence for human factor IX. The isolated DNA sequence and its flanking sequences are useful for determining mutations, deletions or other modifications in genetic sequences expressing normal factor IX or modifications thereof.

REFERENCES:
patent: 4497796 (1985-02-01), Salser
Fujikawa, K. et al., (1973) Biochemistry, vol. 12: pp. 4938-4945, "Isolation and Characterization of Bovine Factor IX".
DiScipio, R. G. et al., (1977), Biochemistry, vol. 16: pp. 698-706, "A Comparison of Human Prothrombin, Factor IX (Christmas Factor Factor X (Stuart Factor), and Protein S".
Katayama, K. et al., (1979), Proc. Natl. Aca. Sci, USA, vol. 76: pp. 4990-4994, "Comparison of Amino Acid Sequence of Bovine Coagulation Factor IX (Christmas Factor) with that of other Vitamin K-Dependent Plasma Proteins".
DiScipio, R. G. et al., (1978), J. Clin. Invest., vol. 61: pp. 1528-1537, "Activation of Human Factor IX (Christmas Factor)".
Choo, K. H. et al., (1982), Nature, vol. 299: pp. 178-180, "Molecular Cloning of the Gene for Human Anti-Haemophilic Factor IX".
Wallace, R. B. et al. (1981), Nucleic Acids Research, vol. 9, pp. 879-894, "The Use of Synthetic Oligonucleotides as Hybridization Probes".
Fujikawa, K. et al. (1974), Biochemistry vol. 13: pp. 4508-4516, "The Mechanism of Activation of Bovine Factor IX (Christmas Factor) by Bovine Factor IXa (Activated Plasma Thromboplastin Antecedent)".
Hedner, U. and Davie, E. W. (1982) In: Hemostasis and Thrombosis, Colman, R. W., Hirsch, J., et al., eds., J. B. Lippincott Co., Philadelphia, Pa., pp. 29-38, "Factor IX".

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