DNA polymorphisms in sterol-regulator-element binding proteins

Details DNA polymorphisms in sterol-regulator-element binding proteins DNA polymorphisms in sterol-regulator-element binding proteins

2011-06-14

2011-06-14

Babic, Christopher M. (Department: 1637)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S975000, C536S023100

Reexamination Certificate

active

07960108

ABSTRACT:
The invention relates to DNA polymorphisms in sterol regulator element binding proteins (SREBP) that are characteristic of a higher risk of genetic diseases in humans such as hyperchlolesterolemia. The corresponding polymorphisms, especially the polymorphisms on SREBP-1 and SREBP-2 are frequently observed in Alzheimer patients (SREBP-2). They are also characterized by a specific behavior in the therapy of HIV patients with proteas inhibitors and appear to have an influence on the mortality.

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Hua et al. “Structure of the Human Gene Encoding . . . (SREBF1) and Localization . . . to Chromosomes 17 p11.2 and 22q13” Genomeics vol. 25, No. 3, 1995, pp. 667-673, XP-000979463.
Shimano et al. “Elevated Levels of SREBP-2 . . . for a Targeted Disruption of the SREBP-1 Gene”, Journal of Clinical Investigation, vol. 11, No. 8, 1997, pp. 2115-2124 XP-002931070.
Pai et al. “Differential Stimulation of Cholesterol . . . Expressing Individual Nuclear Sterol Regulatory Element-binding Proteins”, Journal of Bio. Chem., vol. 273, No. 40, Oct. 2, 1998, pp. 26138-26148.
English translation of Miserez “Die Bedeutung genetisher Faktoren bei der Enstehung des Herzinfarkts”, Uni Nova, Wissenschaftmagazin der Universitat Basel, Online! vol. 81, Apr. 1998 (in German) XP-002159139.
Roy et al. (Cell (1995) 80:167-178).
http://bacpac.chor.org/clones.htm (accessed Dec. 2005).
Wacholder et al. (J. Natl. Cancer Institute (2004) 96(6)L434-442).
Genbank Accession No. AC122129, Date: Jan. 6, 2003.

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