Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease
Patent
1995-03-10
1997-05-27
Hendricks, Keith D.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Transferase other than ribonuclease
536 232, 530350, C12N 912
Patent
active
056331592
ABSTRACT:
Mycobacteriophage DS6A has been characterized and found to specifically infect all species of the TB complex, without any detectable infection of mycobacteria species other than those of the TB complex. DNA sequence analysis revealed several potential open reading frames, including one encoding a protein analogous to gp37 of mycobacteriophage L5 and a second encoding a protein with significant homology to the S. coelicolor DNA polymerase .beta. subunit. Based on the DNA sequence analysis, cloning sites can be identified for insertion of reporter genes, making DS6A useful as a reporter phage for specific detection and identification of species of the TB complex.
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patent: 5476768 (1995-12-01), Pearson et al.
W. B. Redmond and J. C. Cater "A bacteriophage specific for Mycobacterium tuberculosis, varieties hominis and bovis" Amer. Rev. Resp. Dis. 82:781-786 (1960).
B. U. Bowman "Properties of Mycobacteriophage DS6A I. Immunogenicity in rabbits" PSEBM 131:196-200 (1969).
P. R. J. Gangadharam and C. E. Stager "Loss of acid-fastness of Mycobacterium tuberculosis H37Rv following infection by Mycobacteriophage DS6A" Tubercle 57:203-205 (1976).
L. Sula, et al. "Therapy of experimental tuberculosis in guinea pigs with mycobacterial phages DS-6A, GR-21 T, My-327" Czech. Med. 4:209-214 (1981).
W. R. Jacobs, et al. "Rapid assessment of drug susceptibilities of Mycobacterium tuberculosis by means of luciferase reporter phages" Science 260:819-821 (1993).
Beyer, Jr. Wayne F.
Dickson Julie A.
Hamilton Paul T.
Little Michael C.
Pearson Robert E.
Becton Dickinson and Company
Fugit Donna R.
Hendricks Keith D.
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